>>76554179
>>76554231
Fisetin is also *very recently* discovered hit on CXCL12 inhibitors...
>bioRxiv Posted August 18, 2025.
>Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12
>https://www.biorxiv.org/content/10.1101/2025.08.13.670216v1.abstract
>Senescent endothelial cells exhibited elevated expression of SASP factors, particularly Cxcl12, which was reversed by fisetin supplementation, with responses also reflected in circulating CXCL12 concentrations.