Saw this in a /v/ thread and wanted to add that the Spamton NEO battle theme also has something alluding to hands as well.
https://voca.ro/1heatfunrqFV
>Change is coming from the inside of the phone
>A hand that plays until you're all alone
>It pulls strings and makes them ring
>Until your heart turns to red, ah.
I haven't kept up with speculation on this since chapter 2 released, so I could have just missed it, but I haven't seen anyone mention BIG SHOT in relation to the ongoing hand motif in the story and thought I'd bring it up.