>>518636208
Hell I can keep going really
https://pmc.ncbi.nlm.nih.gov/articles/PMC9513661/
The only transcripts where variants were present at higher levels in older mice than younger were those from the non-coding region (i.e. D-loop) (Supplementary Fig. 2). This is true in both oocytes and cumulus cells. The significance of transcripts from this region is unclear, though the data are consistent with previous studies documenting age-related accumulation of mutations in D-loop mtDNA (Arbeithuber et al. 2020). The distribution of the data shows that the majority of mtRNA variants in both oocytes and cumulus cells are found at low levels (<10%). Variants found at >50% (i.e. constituting a majority of the mtRNA population) were uncommon across both sample types, but were present to higher degree in cumulus cells (2/762 vs 25/1649).
>B-b-but they're non coding!
>Ack!!!
https://pubmed.ncbi.nlm.nih.gov/27841002/
However, taken together, a wide variety of recent studies have suggested that miRNAs, piRNAs, endogenous siRNAs, and long non-coding RNAs are the most common regulatory RNAs, and, significantly, there is a growing body of evidence that regulatory non-coding RNAs play an important role in epigenetic control. Therefore, these non-coding RNAs (ncRNAs) highlight the prominent role of RNA in the regulation of gene expression. Herein, we summarize recent research developments with the purpose of coming to a better understanding of non-coding RNAs and their mechanisms of action in cells, thus gaining a preliminary understanding that non-coding RNAs feed back into an epigenetic regulatory network.