>>718116572
They really aren't that bad, weak runs with them are atrocious but once you have a decent run going you can stomp your way through the rest of the run with little issue.
Their big weakness is how easy it is to get hit and lose on your devil/angel deals, which really hurts your run in the long term.
Tainted Laz is way worse, you are almost guaranteed to be forced to juggle with a shit run for half of the rooms in the game.