>>712390553 (OP)Underrail is this
Many different poisons, many ways to acquire them, many ways to apply them, such as via traps, caltrops, thrown knives, bladed weapons and crossbow bolts, but in order to really make them work you need to specialise in them which weakens you elsewhere and you still need to specialise in a specific weapon focus, you can't wholly branch across all avenues of poison application
Even then, you need to invest into biology to extract poisons and even work into some crowd control to give poison time to actually work
There are also beings which ignore poison entirely so you need more investment into dealing with those, but grenades require no skill thankfully
Underrail does have a pretty good array of poisons to play with though, not just DoT boring shit
Shame they're only really viable on lower difficulties, but on those difficulties you can just sleep through the game