Persons with transsexualism, after sex reassignment, have considerably higher risks for mortality, suicidal behavior, and psychiatric morbidity.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016885
>"The most thorough follow-up of sex-reassigned people ā extending over thirty years and conducted in Sweden, where the culture is strongly supportive of the transgendered ā documents their lifelong mental unrest. Ten to fifteen years after surgical reassignment, the suicide rate of those who had undergone sex-reassignment surgery rose to twenty times that of comparable peers." - Dr. Paul McHugh, former Johns Hopkins Psychiatrist in Chief
"15 years after sex reassignment operation, quality of life is lower in the domains of general health, role limitation, physical limitation, and personal limitation."
https://pubmed.ncbi.nlm.nih.gov/18990387/
After surgery 47% are dependent on social support compared to 41% before surgery
https://pubmed.ncbi.nlm.nih.gov/9075286/